Currently I run, on my personal laptop, these active security tools:
- eljefe (client) - Basically a client that reports processes information to the eljefe server (truthfully the tool is very cludgy and i'm only running it because i'm testin it out)
- Microsoft Security Essentials
- Windows 7 Firewall
- Also, all logging/auditing is enabled for windows and the firewall
Currently I run, on my personal desktop, these active security tools:
Additionally, i'll use the built in tools as well as Truecrypt, keepass, glary's utilities, and some other odds and ends of clean-up tools (For some reason I'm obsessed with cleaning the white-space of my laptop and desktop). As for anti-malware I use Malwarebytes (along with Windows Security Essentials as i listed above).
Alright, these are for common use...... if i'm doing sec auditing/vuln assessment I'll boot into either an XP partition with some tools which has practically no defenses or a live CD/USB (ie BackTrack).
Is this really the type of response you were looking for, or is there something else you're going after?
If you'd like some more specific ideas, please post them. It seems like you're an apple user, and that's a whole different beast to tame.