A zero-day (or zero-hour or day zero) attack or threat is an attack that exploits a previously unknown vulnerability in a computer application, meaning that the attack occurs on "day zero" of awareness of the vulnerability.

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What are the areas to focus on to protect users and devices?

What are the areas or technologies to focus on to protect users and devices? Are patching, antivirus and firewalls still the main areas? How do you defend against attacks against vulnerabilities ...
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How do you defend specifically against attackers utilizing any or all of the commercial exploit kits?

There are several commercial exploit kits available containing 0day vulnerabilities: White Phosphorus Exploit Pack http://www.immunityinc.com/products-whitephosphorus.shtml Agora Exploit Pack ...
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Designing in zero day attack mitigations

What are best practices / recommendations / strategies for mitigating zero day threats/attacks from a software development perspective?