A zero-day (or zero-hour or day zero) attack or threat is an attack that exploits a previously unknown vulnerability in a computer application, meaning that the attack occurs on "day zero" of awareness of the vulnerability.

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How do you defend specifically against attackers utilizing any or all of the commercial exploit kits?

There are several commercial exploit kits available containing 0day vulnerabilities: White Phosphorus Exploit Pack http://www.immunityinc.com/products-whitephosphorus.shtml Agora Exploit Pack ...
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Designing in zero day attack mitigations

What are best practices / recommendations / strategies for mitigating zero day threats/attacks from a software development perspective?