It had, over HTTPS port (443):

TLS-SNI-01

But for security reason it's now (mostly) disabled:

https://community.letsencrypt.org/t/important-what-you-need-to-know-about-tls-sni-validation-issues/50811

https://community.letsencrypt.org/t/february-13-2019-end-of-life-for-all-tls-sni-01-validation-support/74209

TLS-SNI-03 is in progress:

https://tools.ietf.org/html/draft-ietf-tls-sni-encryption-03

But it's not yet available

It had, over HTTPS port (443):

TLS-SNI-01

But for security reason it's now (mostly) disabled:

https://community.letsencrypt.org/t/important-what-you-need-to-know-about-tls-sni-validation-issues/50811

https://community.letsencrypt.org/t/february-13-2019-end-of-life-for-all-tls-sni-01-validation-support/74209

TLS-SNI-03 is in progress:

https://datatracker.ietf.org/doc/html/draft-ietf-tls-sni-encryption-03

But it's not yet available