I'm posting this three weeks after a malware and keylogger scare that happened through Skype, and my own negligence, which resulted in a fresh install of Windows 7.
Everything's running and clean, but after a couple of weeks of using Skype again and monitoring activity with TCPview, I noticed there were two IPs that were slowly but surely sending and receiving packets from Skype, while Skype was idle.
Closing one of the connections closed the other at nearly the same time, and they haven't shown up since. Looking up the two IP's (while ignoring the extensions) showed they were possibly coming from home networks with AT&T U-verse and CableOne from the DFW area and Southeast Arizona, respectively.
Should I be worried or suspicious about this? At first I wasn't, but then I remembered that Skype ditched the p2p setup back in July, so I have no clue why there'd be a connection like this.