Is fb2 & epub files can be malicious like pdf? If yes, so how I can detect it manually ?
Malicious RTF, doc, docx, xls, ppt files can be detected via OLETOOLS. Malicious PDF files via peepdf, pdfid & others.
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What is EPUB?
EPUB is an e-book file format with the extension .epub that can be downloaded and read on devices like smartphones, tablets, computers, or e-readers.
Can EPUB file contain malicious code?
Here is another example of how epub had security flaw in past: XML External Entities
Are epub files often used by malware authors?
No. Compared to PDF and others formats epub is rarely used by attackers.
Search in header of file for:
6D 69 6D 65 74 79 70 65 61 70 70 6C 69 63 61 74 69 6F 6E 2F 65 70 75 62 mimetypeapplication/epub
More about epub/epub2 and epub3 go here - http://epubzone.org/news/epub-3-and-interactivity