I saw a few breaches on a very large scale where an organization like JP Morgan suffered a huge breach just by allowing their employees to connect via VPN to their machines at work. Seems that hackers took over JP. Morgan employee computer to connect to his machine at work. Usually, employees connecting to their desktop at work via VPN program that been developed by a company, 2FA and of course they use their own protection measure like a reverse proxy in the backend. I was trying to understand how a company like that could be hacked and what are the possible measures to take for such organizations.
Link to JP. Morgan Study: https://www.sans.org/reading-room/whitepapers/casestudies/minimizing-damage-jp-morgan-039-s-data-breach-35822