If you're serious about it, you could look into installing Qubes as your main OS, and running Whonix in one of the Qubes.
Qubes was a project started by Joanna Rutkowska (who developed the idea of the Blue Pill virtualisation rootkit).
Qubes takes an approach called security by compartmentalization, which allows you to compartmentalize the various parts of your digital life into securely isolated compartments called qubes.
Whonix is based on Debian and Tor and utilizes two VMs, a “gateway” and a “workstation”. Qubes security architecture makes use of Whonix’s isolation by using the gateway as a ProxyVM to route all network traffic through Tor, while the workstation is used for making AppVMs.
Between the two of those (and some reading around common mistakes as mentioned by @Peter Harmann) might see you as best protected as possible.
[Edit] To further the answer, to potentially address issues raised in the comments regarding advice, there are some discussions raised over on tor.stackexchange which might add some clarity:
Comparison of Whonix and Tails
Threat model that Qubes is most appropriate for (including an answer from a whonix maintainer)