Delivery from the MUA is usually done to the domain specific mail provider (MSA in your image). This communication is typically done either inside a companies protected network or to some external mail provider. Mail delivery inside the local network is usually protected against DNS spoofing as long as it can be assumed that there is no attacker inside the local network or that he will not make itself easily visible with DNS spoofing. When using an external mail provider the connection is usually protected by TLS. TLS will protect against DNS spoofing and other traffic rerouting since the MUA will check the subject of the certificate and that it was issued by a trusted CA etc. TLS will also protect against sniffing and modifying the traffic even if the attacker manages to get in the path of mail delivery.
As for MTA/MSA to MTA/MDA communication: this happens on networks where DNS spoofing is not easy too, i.e. this is not on some public hotspot where an attacker could easily inject himself. Additionally DNSSec might be used although lots (if not most) DNS MX/A/AAAA records are currently not protected by DNSSec. But using DNS spoofing to target a specific mail is impossible due to all the caching of DNS. Using it to target all mails to a specific domain is hard too since these might come from various sources which means DNS spoofing might need to be done in various places which might make the attack too visible. The same is true for other ways to reroute the traffic, like BGP hijacking. If the attacker still manages to actively get in the path of the mail delivery though he can likely sniff and modify the traffic since usually there is no TLS enforced between MTA or that the MTA don't properly check the certificates.
None of this actually makes attacks really impossible, it only makes it less likely in most cases. Well-equipped attackers (like governments) will likely be able to mount attacks especially against less protected domains. They might not necessarily attack delivery between MTA/MSA/MDA though since such attacks are more visible to others. Instead they might do a more targeted and less visible attack directly against the victims MDA or the victims mailboxes. The latter is often done using phishing mails to get the users mail account credentials or by delivering malware to attack the victims computer and thus get access to the mails too.